This is primarily a collection of letters and manuscripts sent to Wistar by prominent men who were among his many correspondents. These documents reflect his broad interests, including botany, paleontology, medicine, the American Philosophical Society, and André Michaux's plans for exploring the Missouri.

This correspondence is principally concerned with business between Pershouse and his brother James in England, with comments on conditions and events in the United States, including anti-British feeling, Thomas Paine's return to America, Jefferson's administration, and immigration. The papers include Pershouse's journal (1800-1838), which includes accounts of travels in England, France, and the United States, letterbooks (1836-1862) of Henry Pershouse, nephew of John, chiefly on business matters, and two volumes of Pershouse genealogical data, compiled by B.M. Pershouse Bayley (1899).

After emigrating from Germany to Philadelphia in 1796, Peter Adolph Grotjahn established himself within the city's mercantile community, trading opportunistically both inland and coastwise as far as the Caribbean. In 1812, he began publishing a commercial newspaper, Grotjan's Philadelphia Public Sale Reports and he became increasingly active in local Democratic Party politics. The APS copy of Peter Grotjahn's memoir is a typescript copy of an original volume held at the Historical Society of Pennsylvania. Written for his grandchildren, the memoir begins with a relatively brief genealogical discussion, but concentrates on his personal and political life and commercial experiences prior to 1817. The last section of the autobiography was completed posthumously from notes, and includes extracts from Grotjahn's diary as late as 1844.

This collection contains miscellaneous letters and papers relating to explorations of South America, Cuba, and Mexico; scientific investigations; Latin American antiquities and linguistics; and publications. There are also copies of 26 letters from Humboldt to Pierre Hyacinth Azais and Jules Berger de Xivrey, from originals at the Duke University Medical Center Library.

In addition to family and business correspondence, the Charles Nicoll Bancker Family Papers contains various documents, such as a furniture inventory volume (30pp.); a Daybook, 1795-1800 (120pp.); and a very interesting journal (unidentified, but by one of the Banckers, and filed under "Description of a trip..."), from New York to Albany and back, between July 20-Aug. 15, 1793 (1 vol., 31 pp.). It contains detailed observations of the Hudson River and the towns along the way. Bancker was involved in business and trade prior to 1826, and in insurance after that date, so there is material relating to those topics in this collection. He owned a substantial library of the period, which was used by Charles Wilkes's Expedition after 1837 (see Reynell Coates to Bancker). This library, along with Bancker's notable scientific instrument collection, was sold after his death and there are published auction catalogues in the collection. There is much family correspondence from: Anne E. Bancker, Charles Gerard Bancker, Evert Bancker, Sarah U. Bancker, Violetta Bancker Talbot, Elizabeth Bancker Teackle, and John Teackle.